Nicholl’s men aim to bounce back
Injuries are the reason for the majority of the replacements.
Gareth Beatty and Cathal Cregan come into the front row with Paul McFeely and Jonny Lyons coming into the second row and back row respectively.
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Hide AdMark Robinson the former Queens player who joined the club a couple of weeks ago makes his debut at Out Half and Under 19 player Jack Hargan makes his first start on the wing with Andrew Semple returning to play at full back.
City of Derry lost only their second game in the All Ireland League in the past twelve months away to Queens last Saturday and will be hoping to get back to winning ways against Harlequins.
City of Derry: Gareth Beattie, Cathal Cregan, Sam Duffy, Chris Cooper, Paul McFeely, Stephen Corr, Jonny Lyons, Richard Baird, Jack Caithness, Mark Robinson, Jack Hargan, Neil Burns, Josh Lewis, William McCleery, Andrew Semple. Replacements: Jason Mitchell, Stephen Jefferson, Scott Caithness, Mario Giacomoni, Tiernan Thornton.