The man who died in a two-vehicle road crash near Omagh on Saturday night was Paul Mills.
Police said the 49-year-old was from the Omagh area.
The head on collision involving a Toyota Yaris and a Sabb Vector was reported to police shortly after 10pm.
Mr Mills who was driver of the Yaris was taken to hospital but died from his injuries.
The 40 year old female driver of the other vehicle was also taken to hospital for treatment to non-life threatening injuries.
She has now been arrested.
Inspector Stephen Humphries is appealing for witnesses: “We have spoken to a number of witnesses however we know that other motorists who have not yet come forward were travelling on the road last night and they may have information that could assist in the investigation.
“We would also like to speak to anyone who may have witnessed an earlier collision between the Saab and a white Peugeot 207. The number to call is 101.”